C allele in transforming growth factor-β1 rs1800471 gene polymorphisms might indicate a protective feature in encapsulating peritoneal sclerosis development

BORA F., Aslan B., SARI F., Yılmaz F., Ersoy F. F., KÖKSOY S., ...Daha Fazla

Therapeutic Apheresis and Dialysis, cilt.27, sa.2, ss.353-360, 2023 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 27 Sayı: 2
  • Basım Tarihi: 2023
  • Doi Numarası: 10.1111/1744-9987.13913
  • Dergi Adı: Therapeutic Apheresis and Dialysis
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.353-360
  • Anahtar Kelimeler: encapsulating peritoneal sclerosis, gene polymorphism, peritoneal dialysis, rs1800471, TGF-beta 1, EPITHELIAL-MESENCHYMAL TRANSITION, TURKISH PATIENTS, TGF-BETA-1 GENE, TGF-BETA/SMAD, RISK-FACTORS, IFN-GAMMA, TNF-ALPHA, FIBROSIS, DIALYSIS, ASSOCIATION
  • Kayseri Üniversitesi Adresli: Hayır

Özet

© 2022 International Society for Apheresis and Japanese Society for Apheresis.Introduction: Peritoneal fibrosis may progress in peritoneal dialysis (PD) patients to a fatal clinical condition called encapsulating peritoneal sclerosis (EPS). Transforming growth factor (TGF)-β plays a pivotal role in the pathogenesis of peritoneal fibrosis. We aimed to investigate the association among polymorphisms in the gene encoding TGF-β1, which were −509C/T (rs1800469), +869T/C (rs1982073), and +915G/C (rs1800471) in EPS patients. Methods: A total of 16 PD patients who were clinically and radiologically diagnosed with EPS were enrolled and 22 age- and gender-matched PD patients were selected as the non-EPS group. Results: G allele frequency at the rs1800471 gene polymorphism was significantly higher in the EPS group than non-EPS group (p = 0.005). Interestingly, the non-EPS group patients had CC or CG polymorphisms. Conclusion: C allele in TGF-β1 rs1800471 gene polymorphisms might indicate a protective feature in EPS development. Knowing the presence of polymorphism may be effective in selecting renal replacement therapy in patients.