Cytotoxic Effects of Methanolic Extracts from Different Cladonia Species on Human Colon Cancer Cell Line


Kocakaya Z. , Şeker Karatoprak G., Kocakaya M., Barak M. Ü.

International Ecology 2018 Symposium, Kastamonu, Türkiye, 19 - 23 Haziran 2018, ss.1055

  • Yayın Türü: Bildiri / Özet Bildiri
  • Basıldığı Şehir: Kastamonu
  • Basıldığı Ülke: Türkiye
  • Sayfa Sayıları: ss.1055

Özet

Introduction: Lichens produce a large number of secondary metabolites of great interest due to antiviral, anti-microbacterial, antitumor, anti-allergic, inhibitory activities of plant growth and the like. It has been suggested that the extracts of Cladonia species, including Cladoniaceae family, were used for different medicines in the folk medicine. In this study we aimed to investigate the effects of the extracts of Cladonia pyxidata (L.) Hoffm. and Cladonia coniocraea (Flörke) Spreng.on colon cancer (Colo 205) with in vitro cytotoxicity assay.

Material and Methods: Within the scope of this study, 70% methanol extracts of Cladonia species, were prepared. Cytotoxic effects on Colo 205 cell line were studied with MTT assay.

Results: It has been elucidated that Cladonia coniocraea extract was found to be most cytotoxic extract with 191,45 μg/mL IC50 value on Colo 205 cell line.

Discussion: Among the two Cladonia species studied, C. coniocraea was found promising on Colo 205 cell line. The inhibitory effect of C. coniocraea extract on colon cancer cell line at different concentrations for 48 and 72 h will be examined in our subsequent studies.