Development of Lateral Flow Assays for Rapid Detection of Troponin I: A Review

Mohammadinejad A., Nooranian S., Kazemi Oskuee R., Mirzaei S., Aleyaghoob G., Zarrabi A., ...More

Critical Reviews in Analytical Chemistry, vol.8, pp.13-27, 2022 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 8
  • Publication Date: 2022
  • Doi Number: 10.1080/10408347.2022.2144995
  • Journal Name: Critical Reviews in Analytical Chemistry
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aerospace Database, Aqualine, Aquatic Science & Fisheries Abstracts (ASFA), Biotechnology Research Abstracts, Chemical Abstracts Core, Chimica, Communication Abstracts, Compendex, EMBASE, Environment Index, Geobase, MEDLINE, Metadex, Civil Engineering Abstracts
  • Page Numbers: pp.13-27
  • Keywords: Network embedding, Graph convolution, Graph autoencoder, Temporal networks, LINK-PREDICTION
  • Kayseri University Affiliated: No


© 2022 Taylor & Francis Group, LLC.Troponin I as a particular and major biomarker of cardiac failure is released to blood demonstrating hurt of myocardial cells. Unfortunately, troponin I detection in the first hours of acute myocardial infarction usually faces with most negligence. Therefore, developments of point of care devices such as lateral flow strips are highly required for timely diagnosis and prognosis. Lateral flow assays are low-cost paper-based detection platforms relying on specific diagnostic agents such as aptamers and antibodies for a rapid, selective, quantitative and semi-quantitative detection of the analyte in a complex mixture. Moreover, lateral flow assay devices are portable, and their simplicity of use eliminates the need for experts or any complicated equipment to operate and interpret the test results. Additionally, by coupling the lateral flow assay technology with nanotechnology, for labeling and signal amplification, many breakthroughs in the field of diagnostics have been achieved. The present study reviews the use of lateral flow assays in early stage, quantitative, and sensitive detection of cardiac troponin I and mainly focuses on the structure of each type of developed lateral flow assays. Finally, this review summarized the improvements, detection time, and limit of detection of each study as well as the advantages and disadvantages.