Chronic Granulomatous Disease with Recurrent Tuberculosis at Adolescent Child Tekrarlayan Tüberküloz ile Kronik Granülomatöz Tanısı Konulan Adölesan

Kökcü Karadağ Ş. İ., Kutluğ Ş., Uzun O., KÖKER M. Y., Yıldıran A.

Cocuk Enfeksiyon Dergisi, vol.16, no.2, 2022 (ESCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 16 Issue: 2
  • Publication Date: 2022
  • Doi Number: 10.5578/ced.20229808
  • Journal Name: Cocuk Enfeksiyon Dergisi
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, CINAHL, EMBASE
  • Keywords: Chronic granulomatous disease, recurrent tuberculosis, aspergillosis
  • Kayseri University Affiliated: No


© 2022 by Pediatric Infectious Diseases and Immunization Society.Chronic granulomatous disease (CGD) is an a primary immunodeficiency characterized by recurrent severe bacterial and fungal infections due to defects in the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase system. Both extracellular and intracellular pathogens such as mycobacterium tuberculosis also cause important infectious diseases in these patients. The diagnosis is usually made in early childhood. However, partial enzyme deficiencies may delay the diagnosis. We presented a patient who first had recurrent tuberculosis infectious disease and later developed pulmonary aspergillosis and was diagnosed with CGD. Primary immune deficiency should be considered in the differential diagnosis in cases of recurrent tuberculosis infectious disease. Patients with primary immunodeficiency, such as CGD, may be contracted by recurrent tuberculous infectious disease before developing invasive pulmonary aspergillosis. In this way, at least in some patients, the infectious disease can be controlled more effectively and the recurrence of the infectious disease can be prevented.