The management approach that focuses on the development of employees is gaining importance day by day for healthcare businesses that provide healthcare services supply, as it is in every sector. The high level of specialization and the use of intensive knowledge and technology in health enterprises increase this necessity. Issues such as employees exhibiting innovative behaviors, to be found in innovative work behaviors and employee creativity are becoming priority areas in health service delivery. In these practices, which develop positive outputs for businesses, leaders who support development are needed. This leadership style, which focuses on the success of subordinates instead of focusing on their own personal interests and development, is emphasized as entrepreneurial leadership. In the philosophy of entrepreneurial  leadership, achieving corporate goals and objectives can be realized by supporting the creativity and development of subordinates. In this context, the main purpose of entrepreneurial leadership is to ensure the individual and professional development of subordinates. However, while focusing on the success of subordinates, psychological support is also needed to make them feel powerful in their work-related activities. In this direction, the mediating effect of psychological empowerment in the effect of entrepreneurial leadership on employee creativity will be examined within the scope of the research. According to the research findings, it was determined that entrepreneurial leadership is positively related to employee creativity and psychological empowerment. As a result of multiple regression analysis, psychological empowerment shows partial mediation in the relationship between entrepreneurial leadership and employee creativity. As a result, entrepreneurial leadership theory can be expressed as an important concept for employee creativity in healthcare businesses. In addition, it is predicted that employees who feel psychologically strong can engage in more creative initiatives.