The Effect of Cerebrolysin on Ischemia Reperfusion-Induced Oxidative and Inflammatory Ovarian Damage in Rats

Ozer M., Ince S., SÜLEYMAN B., MAMMADOV R., Yavuzer B., Bulut S., ...More

Latin American Journal of Pharmacy, vol.41, no.6, pp.1223-1232, 2022 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 41 Issue: 6
  • Publication Date: 2022
  • Journal Name: Latin American Journal of Pharmacy
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, EMBASE, International Pharmaceutical Abstracts
  • Page Numbers: pp.1223-1232
  • Keywords: cerebrolysin, infertility, ischemia-reperfusion, ovarian damage, rat, ISCHEMIA/REPERFUSION INJURY, PREVENTION, TISSUE
  • Kayseri University Affiliated: No


© 2022, Colegio de Farmaceuticos de la Provincia de Buenos Aires. All rights reserved.SUMMARY. Ovarian ischemia-reperfusion (I/R) injury develops due to oxidative stress and inflammation that occurs when tissue is deprived of oxygen. Ovarian I/R damage also causes infertility. The aim of this study is to see the effect of ovarian I/R damage on reproductive functions and to determine the protection of antioxidant and anti-inflammatory cerebrolysin in possible damage. Albino Wistar-type female rats were divided into sham operation (SG), ischemia-reperfusion (IR) and cerebrolysin+ischemia-reperfusion (CIR) groups. After I/R application with cerebrolysin, the ovaries of six animals from each group were taken and biochemical and histopathological examinations were performed. Six animals from each remaining group were left to breed. Our test results showed that cerebrolysin decreased I/R-related oxidant, proinflammatory cytokine and tissue damage and increased antioxidant levels. In addition, cerebrolysis significantly inhibited the delay of the maternity period. These findings indicate that cerebrolysin may be helpful in the treatment of I/R-related ovarian damage and infertility.