© 2022 Elsevier B.V.The present paper addresses an ecological machining method in turning Hastelloy C 276 Nickel alloy under different conditions such as dry, oil with least quantity lubrication (LQL), and graphene-based nanofluid LQL (NFLQL) by changing the cutting speed (31, 46, and 62 m/min) and feed rate (0.1, 0.15 and 0.2 mm/rev). Four machining responses were studied namely: surface roughness, tool wear, cutting temperature, and chip thickness. The wettability, pH value, and stability of the nanofluids were assessed prior to the machining process. The output revealed that the usage of NFLQL enhanced the machining performance in contrast to the oil LQL and dry conditions. The average reduction in the surface roughness with NFLQL condition is about 66% compared to dry machining. In addition, NFLQL gives the lowest cutting temperature (40 °C), flank wear (0.053 mm), and chip thickness (0.16 mm) respectively. In a nutshell, the effective cooling and lubrication ability of NFLQL has made significant contributions to smoother machining.