© 2022 Elsevier B.V.Deep eutectic solvents (DESs), a new class of environmentally friendly solvents, are gaining more attention from researchers for extracting and separating targeted analytes from different complex samples. DESs are liquid at room temperature and contain a hydrogen bond donor and a hydrogen bond acceptor. DESs are non-volatile solvents, have excellent thermal and electrical stability, and can easily dissolve a number of organic and inorganic substances. DESs have attracted a lot of attention as new green solvents are expected to take the place of traditional organic solvents. DESs are sustainable solvents that concern significant interest from researchers and various industries. They are non-flammable, chemically stable, biocompatible, biodegradable, and have low volatile content. DESs have tunable physicochemical properties that can be tailored to meet the needs of a definite task. This review summarizes the DESs-based adsorbent materials and its preparation characterizations and application by highlighting the unique properties such as extraction and separation applications. To summarize the DESs-based applications, this review reported up-to-date data related to this field. and also provide an easy and single path to cover the DESs-based materials and its adsorption applications. This review exploits new DESs and DESs-based materials that are diversifing into extraction and separation due to the development of DESs.