Research Information System
Acta cirurgica brasileira, vol.35, 2020 (Journal Indexed in SCI)
Purpose: To evaluate the effects of meperidine on fascial healing.
Methods: Seventy adult male Sprague-Dawley rats divided into 7 groups with 10 rats in each group.
One of these groups was determined as the sham group, 3 of the remaining 6 groups as meperidine
groups, and 3 as control groups. These were grouped as 1st, 2nd, and 6th weeks. In the anterior
abdominal wall of the rat, the skin was detached and a wound model including the peritoneum
was created with a median incision. Mice in the meperidine group were injected with meperidine
intraperitoneally (IP) 3 × 20 mg/kg meperidine on postoperative days 0, 1 and 2, and 2 × 20 mg/kg
meperidine on postoperative days 3, 4, 5, and 6 after surgical intervention. Similar to the control group,
an equal volume of saline was administered, corresponding to the doses. After sacrifice, the midline
fascia was used for facial tensile strength measurement, and the other for histopathological analysis.
Results: When compared, the meperidine and control groups inflammatory cell density was higher in the
1st week (p < 0.05) in the meperidine group, fibroplasia density was found to be higher at the 2nd week in
the meperidine group than the control group (p < 0.05) When the tensile strength in the meperidine and
control groups were compared, there was no significant difference (p > 0.05) at each of the three weeks.
Conclusion: The application of postoperative systemic meperidine affects positively wound healing in
the inflammatory stage and fibroplasia without changing the resistance to traction.