MOLECULAR APPROACHES TO THE COVID 19 IN RESPIRATORY AND IMMUNE SYSTEMS


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Kuşçulu N.

in: Medical and Health Research Theory, Method and Practice, Prof. Dr. Nizami DURAN, Editor, Livre.net , Lyon, pp.92-101, 2021

  • Publication Type: Book Chapter / Chapter Research Book
  • Publication Date: 2021
  • Publisher: Livre.net
  • City: Lyon
  • Page Numbers: pp.92-101
  • Editors: Prof. Dr. Nizami DURAN, Editor

Abstract

The coronavirus family are single-stranded, positive-polarity, nonsegmented,
enveloped pleomorphic viruses with the largest RNA genome.
The large genome causes the virus to be less dependent on the host cell
during replication. Its replication takes place in the cytoplasm of epithelial cells
of the respiratory system and gastrointestinal tract. The term “corona” means
crown in Latin, and the virus takes its name from the crown-like structures in its
structure. In general, the genome size of RNA viruses is usually less than 10 kb,
since the mutation rates in the replication of RNA viruses are much higher than
that of DNA viruses. However, the coronavirus genome has the largest genome
among RNA viruses and is 30 kb in length (1-4).