An interdisciplinary overview of α-PVP

KARİPER İ. A., METİN A., Büyükbezirci K., EKEN A., BAKIR E.

Revue de Medecine Legale, vol.13, no.4, pp.131-138, 2022 (Scopus) identifier

  • Publication Type: Article / Article
  • Volume: 13 Issue: 4
  • Publication Date: 2022
  • Doi Number: 10.1016/j.medleg.2022.09.001
  • Journal Name: Revue de Medecine Legale
  • Journal Indexes: Scopus, EMBASE
  • Page Numbers: pp.131-138
  • Keywords: Chemical properties, Pharmacodynamics, Pharmacokinetics, Psychology, Toxic, α-PVP
  • Kayseri University Affiliated: No


© 2022 Elsevier Masson SASα-PVP has become one of the most dangerous drugs today. α-PVP is chemically the ketone analog of proline. Physically, it is an odorless, colorless solid crystal form. α-PVP is also chemically called α-pyrrolidinovalerophenone, 1-Phenyl-2- (pyrrolidine-1-yl) pentane-1-one, α-Pyrrolidinopentiophenone. In this study, we focused on a general review of this drug, α-PVP, which has become very popular among young people. The study mainly focused on the chemical (synthesis, analogs) and physicochemical (such as density, viscosity, polarity, surface tension) properties, pharmacodynamics, pharmacokinetics, and toxic effects of α-PVP, as well as psychological effects and preventive studies. α-PVP users often appear to cause loss of consciousness, difficulty breathing, and, worst cases, death. It has high toxicity. It has been understood that such a synthetic chemical can be produced in high amounts in a laboratory environment and chemically. The information in the literature on these issues is generally collected in this overview article. In the conclusion part of the study, the negative effects of α-PVP were mentioned, and suggestions were made.