Anticancer and biological properties of new axially disubstituted silicon phthalocyanines†


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Farajzadeh N., Kuşçulu N., Yenilmez H. Y. , Bahar D., Bayır Z.

DALTON TRANSACTIONS, vol.51, pp.4339-4350, 2022 (Peer-Reviewed Journal)

  • Publication Type: Article / Article
  • Volume: 51
  • Publication Date: 2022
  • Doi Number: 10.1039/d2dt01033j
  • Journal Name: DALTON TRANSACTIONS
  • Journal Indexes: Science Citation Index Expanded
  • Page Numbers: pp.4339-4350

Abstract

This study reports the synthesis of three novel axially disubstituted silicon phthalocyanines (1–3-Si) and
their quaternized phthalocyanines (1–3-QSi). The resulting compounds were characterized by applying
spectroscopic techniques including 1H NMR, FT-IR, UV–vis, and mass spectroscopy. The biological properties
of compounds 1–3-QSi, including DNA cleavage activities, DNA binding modes, and topoisomerase
enzyme inhibition activities, were investigated using agarose gel electrophoresis. pBR322 plasmid
DNA, CT-DNA, and AL-DNA (isolated from apricot leaf ) were used for DNA studies. All the quaternized
compounds exhibited acceptable DNA cleavage activities. Human topoisomerase I and E. coli topoisomerase
enzymes were used for the topoisomerase I inhibition studies. All the quaternized complexes inhibited
topoisomerase I activity. Moreover, these compounds were screened for cytotoxic and apoptotic
effects against a human colon cancer cell line (DLD-1) by performing MTT and Annexin V assays. They
exhibited toxicity and apoptotic effect on the DLD-1 cell line. The findings reveal that the compounds can
be utilized for cancer therapy after further investigations.