The protective effect of Myrtus communis L. against experimental kidney stone in rats

Yılmaz H., Ekinci N., Ömerli A., NİSARİ M., YAY A. H., ÜLGER H., ...More

Advances in Traditional Medicine, vol.23, no.1, pp.241-249, 2023 (ESCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 23 Issue: 1
  • Publication Date: 2023
  • Doi Number: 10.1007/s13596-021-00620-4
  • Journal Name: Advances in Traditional Medicine
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus
  • Page Numbers: pp.241-249
  • Keywords: M. communis, Calcium oxalate, Ethylene glicole, Pizzolato's, Staining, Urine
  • Kayseri University Affiliated: No


© 2022, The Author(s), under exclusive licence to Institute of Korean Medicine, Kyung Hee University.The aim of this study is to investigate the protective effect of 70% methanolic extract of Myrtus communis L. leaves (300 mg/kg) against the kidney stone modeling created by (0.75%) ethylene glycole. Twenty-eight, 10 week’s Sprague Dawley male rats were divided into four groups (n = 7) as the control group, ethylene glycol (EG) group, M. communis (MC) group and protective (EG + MC) group. For 28 days, while 0.75% EG was given by adding it to drinking water to occur kidney stone model, MC was given by gavage to test the protective effect. 24 h’ urine samples were taken, and calcium, creatinine, uric acid, magnesium, citrate and oxalate were evaluated. On the 28th day, the rats were sacrificed, and their kidneys were removed. Kidney tissues were examined with hematoxylin eosin (HE) staining and kidney stones formed with Pizzolato’s (PZ) staining technique were shown. M. communis extract brought abnormal urine parameter values closer to the control group. Additionally, it was concluded that the tissue degeneration and number of stones decreased in the protective group. M. communis extract has a protective effect against the kidney stone modeling which created by EG.