Luteolin, a Potent Anticancer Compound: From Chemistry to Cellular Interactions and Synergetic Perspectives

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Singh Tuli H., Rath P., Chauhan A., Sak K., Aggarwal D., Choudhary R., ...Daha Fazla

Cancers, cilt.14, sa.21, 2022 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 14 Sayı: 21
  • Basım Tarihi: 2022
  • Doi Numarası: 10.3390/cancers14215373
  • Dergi Adı: Cancers
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, CINAHL, EMBASE, Veterinary Science Database, Directory of Open Access Journals
  • Anahtar Kelimeler: luteolin, apoptosis and cell cycle, anti-metastasis, anti-inflammation, synergistic action, MULTIPLE SIGNALING PATHWAYS, BREAST-CANCER, COLORECTAL-CANCER, GASTRIC-CANCER, HEPATOCELLULAR-CARCINOMA, OXIDATIVE STRESS, DOWN-REGULATION, CYCLE ARREST, CELLS, APOPTOSIS
  • Kayseri Üniversitesi Adresli: Hayır

Özet

© 2022 by the authors.Increasing rates of cancer incidence and the toxicity concerns of existing chemotherapeutic agents have intensified the research to explore more alternative routes to combat tumor. Luteolin, a flavone found in numerous fruits, vegetables, and herbs, has exhibited a number of biological activities, such as anticancer and anti-inflammatory. Luteolin inhibits tumor growth by targeting cellular processes such as apoptosis, cell-cycle progression, angiogenesis and migration. Mechanistically, luteolin causes cell death by downregulating Akt, PLK-1, cyclin-B1, cyclin-A, CDC-2, CDK-2, Bcl-2, and Bcl-xL, while upregulating BAX, caspase-3, and p21. It has also been reported to inhibit STAT3 signaling by the suppression of STAT3 activation and enhanced STAT3 protein degradation in various cancer cells. Therefore, extensive studies on the anticancer properties of luteolin reveal its promising role in chemoprevention. The present review describes all the possible cellular interactions of luteolin in cancer, along with its synergistic mode of action and nanodelivery insight.