Antimicrobial Phthalocyanines Bearing Flurinated groups on peripheral positions

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Farajzadeh N., Kuşçulu N., Koçak M.

5 th INTERNATIONAL BIOCIDAL CONGRESS, Ankara, Turkey, 5 - 07 March 2021, vol.1, no.1, pp.143

  • Publication Type: Conference Paper / Summary Text
  • Volume: 1
  • City: Ankara
  • Country: Turkey
  • Page Numbers: pp.143
  • Kayseri University Affiliated: Yes


Phthalocyanines as porphyrin analogs include a highly delocalized structure resulting in excellent chemical and physical
properties. Due to their high electron transfer ability, Pcs have attracted attention in a wide range of high-technological fields
such as chemistry, materials, physics, medicine, and nanotechnology as well as their traditional use in the dyes and pigments
industry. Since these applications need soluble Pcs, the Pc ring of unsubstituted Pcs should be modified. There are mainly two
ways to alter the Pc structure: First, insertion of metal ions to the Pc cavity, addition of peripherally and/or non-peripherally
substituents to the Pc periphery [1,2]. Due to the antimicrobial properties of some of the phthalocyanines, they can inhibit the
activity of gram-positive bacteria. Therefore, their potential as antibacterial materials can be studied for the detection and
inactivation of various bacteria. TLC-direct bioautography and Disk diffusion assay are common approaches that have been
performed for this purpose [3,4]. The results confirmed that phthalocyanines exhibit acceptable antimicrobial properties. In
conclusion, the low expense and ease of their synthesis as well as the architectural modifications are some of the factors to
attract extensive attention.