A Simple and Efficient Synthesis of Some Important Pyrazole Derivatives

KORKUSUZ E., YILDIRIM I.

JOURNAL OF THE CHEMICAL SOCIETY OF PAKISTAN, vol.37, no.6, pp.1177-1184, 2015 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 37 Issue: 6
  • Publication Date: 2015
  • Journal Name: JOURNAL OF THE CHEMICAL SOCIETY OF PAKISTAN
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1177-1184
  • Kayseri University Affiliated: No

Abstract

The 1H-pyrazole-3-carboxylic acid was converted via reactions of its acid chloride 1a,b with amino acid, thiol and various amine derivatives into the corresponding amino acid ester derivatives 2a-d, 4-aroyl-1,5-diaryl-1H-pyrazol-3-carbotioates 3a-d, and pyrazole-3-carboxamides 6, 7 respectively, in good yields (35-85%). The structures of all new synthesized compounds were established by the 13C NMR, 1H NMR, IR spectroscopic data and elemental analyses.