Trends of primary glomerular disease in Turkey: TSN-GOLD registry report

Gül C. B., Küçük M., Öztürk S., DEMİR E., EREN N., Şumnu A., ...More

International Urology and Nephrology, vol.54, no.9, pp.2285-2294, 2022 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 54 Issue: 9
  • Publication Date: 2022
  • Doi Number: 10.1007/s11255-022-03123-6
  • Journal Name: International Urology and Nephrology
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, EMBASE, Gender Studies Database, MEDLINE
  • Page Numbers: pp.2285-2294
  • Keywords: IgA nephropathy, FSGS, Kidney biopsy registry, Primary glomerulopathy, RENAL BIOPSY, PRIMARY GLOMERULONEPHRITIS, SPANISH REGISTRY, IGA NEPHROPATHY, EPIDEMIOLOGY, FREQUENCY, ADULTS, PREVALENCE, NATIONWIDE, DIAGNOSIS
  • Kayseri University Affiliated: No

Abstract

© 2022, The Author(s), under exclusive licence to Springer Nature B.V.Background: Although several renal biopsy registry reports have been published worldwide, there are no data on primary glomerular disease trends in Turkey. Methods: Three thousand eight-hundred fifty-eight native kidney biopsy records were assessed in the Turkish Society of Nephrology Primary Glomerulopathy Working Group (TSN-GOLD) Registry. Secondary disease and transplant biopsies were not recorded in the registry. These records were divided into four periods, before 2009, 2009 to 2013, 2013–2017, and 2017–current. Results: A total of 3858 patients (43.6% female, 6.8% elderly) were examined. Nephrotic syndrome was the most common biopsy indication in all periods (58.6%, 53%, 44.1%, 51.6%, respectively). In the whole cohort, IgA nephropathy (IgAN) (25.7%) was the most common PGN with male predominance (62.7%), and IgAN frequency steadily increased through the periods (× 2 = 198, p < 0.001). MGN was the most common nephropathy in the elderly (> 65 years), and there was no trend in this age group. An increasing trend was seen in the frequency of overweight patients (× 2 = 37, p < 0.0001). Although the biopsy rate performed with interventional radiology gradually increased, the mean glomeruli count in the samples did not change over the periods. Conclusions: In Turkey, IgAN is the most common primary glomerulonephritis, and the frequency of this is increasing.