Synthesis of [3,3 '(4H,4 ' H)-Bi-2H-1,3-oxazine]-4,4 '-diones and Their Hydrolysis

Korkusuz E., YILDIRIM İ.

HELVETICA CHIMICA ACTA, vol.96, no.7, pp.1339-1347, 2013 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 96 Issue: 7
  • Publication Date: 2013
  • Doi Number: 10.1002/hlca.201200463
  • Journal Name: HELVETICA CHIMICA ACTA
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1339-1347
  • Keywords: Furan-2, 3-diones, 2H-1, 3-Oxazines, 1H-Pyrazoles, 3, 5-diaryl-, Azines, Cycloadditions, CYCLIC OXALYL COMPOUNDS, AZINES, FURAN-2,3-DIONES, HETEROCYCLES, DERIVATIVES, PYRAZOLES, AGONIST, S32504
  • Kayseri University Affiliated: No

Abstract

The [3,3(4H,4H)-bi-2H-1,3-oxazine]-4,4-diones 3a-3i were obtained by [2+4] cycloaddition reactions of furan-2,3-diones 1a-1c with aromatic aldazines 2a-2d (Scheme1). So, new derivatives of bi-2H-1,3-oxazines and their hydrolysis products, 3,5-diaryl-1H-pyrazoles 4a-4c (Scheme3), which are potential biologically active compounds, were synthesized for the first time.