This was prepared to determine the effect of job insecurity perception on employee motivation and performance. The population of the research consists of medical sales representatives working in national and international pharmaceutical companies operating in Turkey. The survey was conducted using the field research design, one of the quantitative methods. In the survey form; expressions regarding age, gender, marital status, education level and experience period were used to determine the demographic characteristics of the participants in the research. In the survey the job insecurity scale developed by Sverke, Hellgren and Isaksson (1999) was developed by Mottaz (1985) to determine the motivation level of the employee and its suitability for Turkish use was reviewed Dundar et al. (2007) and the performance scale adapted by Çol (2008) were used to measure the employee’s performance. According to the results obtained from this study, medical sales representatives’ perceptions of job insecurity have a positive affect on the performance of medical sales representatives. On the other hand a significant relationship was found between ajob insecurity and employee motivation and performance. In this context, it is thought that the results obtained will contribute by filling the gap in the relevant literature and will be a source of information on relevant issues for the service sector.