Biotechnological advances in Bacillus thuringiensis and its toxins: Recent updates

Azizoğlu U., Jouzani G. S., Sansinenea E., Sanchis-Borja V.

REVIEWS IN ENVIRONMENTAL SCIENCE AND BIO-TECHNOLOGY, cilt.22, sa.2, ss.319-348, 2023 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 22 Sayı: 2
  • Basım Tarihi: 2023
  • Doi Numarası: 10.1007/s11157-023-09652-5
  • Dergi Adı: REVIEWS IN ENVIRONMENTAL SCIENCE AND BIO-TECHNOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, ABI/INFORM, Aqualine, Biotechnology Research Abstracts, CAB Abstracts, Environment Index, Pollution Abstracts, Veterinary Science Database, Civil Engineering Abstracts
  • Sayfa Sayıları: ss.319-348
  • Anahtar Kelimeler: Insect pathogenic bacteria, Microbial biotechnology, Genetic modification, Recombinant DNA, Environmental impacts, ARBUSCULAR MYCORRHIZAL FUNGI, WESTERN CORN-ROOTWORM, PLANT-GROWTH, CRY TOXINS, EUTETRANYCHUS-ORIENTALIS, MELOIDOGYNE-INCOGNITA, INSECTICIDAL ACTIVITY, SUBSP KURSTAKI, STRAIN, BIODEGRADATION
  • Kayseri Üniversitesi Adresli: Evet

Özet

Bacillus thuringiensis (Bt) and its products are commonly used to control insect pests. The main issue with these bacteria is their limited field stability. These constraints fueled interest in using several molecular, biological, and biotechnological techniques to develop new recombinant Bt toxins with a broader insect spectrum, improved environmental stability and more efficient delivery of toxins to pest insects control. However, the potential environmental impact of using recombinant Bt strains and genetically engineered Bt crops includes gene flows into wild species and their unintended consequences on parasitoids and predators. The development of new hybrid/mutated Bt insecticidal toxins, with enhanced insecticidal activity and/or a broader spectrum of target insects, will continue to be a useful strategy for controlling resistant insect pests and delaying resistance evolution. Furthermore, the use of other genes encoding non-Bt proteins with insecticidal properties and different modes of action, such as protease inhibitors, lectins, cholesterol oxidases and chitinases, isolated from various sources will be critical in providing new weapons for the fight against insect damage.This review thoroughly describes recent advances and the most recent updates in the new potential applications of Bt, making it a remarkable new cell factory that can be employed to control pests.