MEDICINAL CHEMISTRY, vol.16, no.6, pp.735-749, 2020 (Journal Indexed in SCI)
Article / Article
Title of Journal :
EGFR/PI3K/AKT pathway, LNCaP, flurbiprofen, thioether, methionine aminopeptidase, prostate cancer, METHIONINE AMINOPEPTIDASE-2 INHIBITOR, ANTI-HCV, PROGRESSION, FUMAGILLIN, TNP-470
Background: Prostate cancer is still one of the serious causes of mortality and morbidity in men. Despite recent advances in anticancer therapy, there is a still need of novel agents with more efficacy and specificity in the treatment of prostate cancer. Because of its function on angiogenesis and overexpression in the prostate cancer, methionine aminopeptidase-2 (MetAP-2) has been a potential target for novel drug design recently.