Synthesis, Anticancer Activity on Prostate Cancer Cell Lines and Molecular Modeling Studies of Flurbiprofen-Thioether Derivatives as Potential Target of MetAP (Type II)


Yilmaz O., Bayer B., Bekci H. , Uba A., CUMAOĞLU A., Yelekci K., ...Daha Fazla

MEDICINAL CHEMISTRY, cilt.16, ss.735-749, 2020 (SCI İndekslerine Giren Dergi) identifier identifier identifier

Özet

Background: Prostate cancer is still one of the serious causes of mortality and morbidity in men. Despite recent advances in anticancer therapy, there is a still need of novel agents with more efficacy and specificity in the treatment of prostate cancer. Because of its function on angiogenesis and overexpression in the prostate cancer, methionine aminopeptidase-2 (MetAP-2) has been a potential target for novel drug design recently.