Synthesis, Anticancer Activity on Prostate Cancer Cell Lines and Molecular Modeling Studies of Flurbiprofen-Thioether Derivatives as Potential Target of MetAP (Type II)

Yilmaz O., Bayer B., Bekci H., Uba A., CUMAOĞLU A., Yelekci K., ...More

MEDICINAL CHEMISTRY, vol.16, no.6, pp.735-749, 2020 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 16 Issue: 6
  • Publication Date: 2020
  • Doi Number: 10.2174/1573406415666190613162322
  • Journal Name: MEDICINAL CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Agricultural & Environmental Science Database, Biotechnology Research Abstracts, EMBASE, MEDLINE
  • Page Numbers: pp.735-749
  • Keywords: EGFR/PI3K/AKT pathway, LNCaP, flurbiprofen, thioether, methionine aminopeptidase, prostate cancer, METHIONINE AMINOPEPTIDASE-2 INHIBITOR, ANTI-HCV, PROGRESSION, FUMAGILLIN, TNP-470
  • Kayseri University Affiliated: Yes

Abstract

Background: Prostate cancer is still one of the serious causes of mortality and morbidity in men. Despite recent advances in anticancer therapy, there is a still need of novel agents with more efficacy and specificity in the treatment of prostate cancer. Because of its function on angiogenesis and overexpression in the prostate cancer, methionine aminopeptidase-2 (MetAP-2) has been a potential target for novel drug design recently.