Investigation of developmental and reproductive effects of resveratrol in Drosophila melanogaster

Atli E., Tamtürk E.

Toxicology Research, vol.11, no.1, pp.101-107, 2022 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 11 Issue: 1
  • Publication Date: 2022
  • Doi Number: 10.1093/toxres/tfab123
  • Journal Name: Toxicology Research
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Aqualine, BIOSIS, Chemical Abstracts Core, EMBASE, Food Science & Technology Abstracts, Pollution Abstracts
  • Page Numbers: pp.101-107
  • Keywords: Drosophila melanogaster, resveratrol, developmental toxicity, reproductive toxicity, endocrine disrupting compounds, ANTAGONIST ACTIVITY, LIFE-SPAN, IDENTIFICATION, AGONIST, FLY
  • Kayseri University Affiliated: No


© 2021 The Author(s). Published by Oxford University Press. All rights reserved.Resveratrol is a chemical that attracts attention due to its antioxidative, anti-inflammatory, and estrogenic/antiestrogenic properties. In the present study, it was aimed to investigate developmental and reproductive effects (developmental periods, average numbers of offspring, sex ratios) of resveratrol in Drosophila melanogaster. Their larvae were exposed to 50, 100, and 200 μM of resveratrol. Resveratrol treatments did not affect pupation and maturation rate (P > 0.05) statistically. But the pupation and maturation times were significantly extended at all doses (P < 0.05). Also, 100 and 200 μM resveratrol treatments resulted in a significant decrease in the number of offspring (P < 0.05). The results reveal that resveratrol, which is generally known for its positive effects, may have negative effects on the development and reproduction of invertebrates. The results of this study support the idea that resveratrol may act as an endocrine disruptor, as it is a phytoestrogen.