An assessment of the relation between vitamin D levels and electroencephalogram (EEG) changes in migraine patients

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CANPOLAT M., Topcu A., KARDAŞ F., Ipekten F., PER H., GÜMÜŞ H., ...More

Bratislava Medical Journal, vol.123, no.2, pp.92-99, 2022 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 123 Issue: 2
  • Publication Date: 2022
  • Doi Number: 10.4149/bll_2022_014
  • Journal Name: Bratislava Medical Journal
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, EMBASE
  • Page Numbers: pp.92-99
  • Keywords: vitamin D, migraine, electroencephalogram, D DEFICIENCY, SEIZURE FREQUENCY, SSRI MEDICATIONS, VEEG MODELS, EPILEPSY, HEADACHE, CHILDREN
  • Kayseri University Affiliated: No

Abstract

© 2022, Bratislava Medical Journal. All rights reserved.BACKGROUND: The present study evaluated vitamin D therapy in migraine patients with vitamin D defi ciency and EEG abnormality. METHODS: 140 patients were divided into four groups: Group A; normal vitamin D and EEG, Group B; low vitamin D and normal EEG, Group C; normal vitamin D and pathological EEG, and Group D; low vitamin D and pathological EEG. Patients with low vitamin D received vitamin D therapy. RESULTS: Paediatric Migraine Disability Assessment Scale (PedMIDAS) scores and median attack frequencies time-dependent changes in the patients receiving vitamin D therapy in Group B were signifi cant (p <0.05), but not in the untreated patients in the Group A (p >0.05). Interictal EEG was pathological in 41 (29.3 %) patients. The main EEG fi ndings were focal/hemispheric spike/sharp wave activity at 9.3 %, bilateral/generalized spike/sharp wave activity at 8.6 %, focal slowing at 5.8 %, and bilateral slow-wave activity/background rhythm irregularity at 3.6 %. Changes in EEG fi ndings in between the groups C and D were not signifi cant (p >0.05). There was no signifi cant association between vitamin D levels <20 or ≥20 ng/ mL and EEG fi ndings in Group D (p >0.05). CONCLUSION: Vitamin D therapy positively affects attack frequency and PedMIDAS scores in migraine patients with vitamin D defi ciency/insuffi ciency. No association was determined between EEG fi ndings and vitamin D levels or therapy (Tab. 6, Ref. 35). Text in PDF www.elis.sk