Invest-gation of vitamin D levels in obsessive-compulsive disorder


Indian Journal of Psychiatry, vol.64, no.4, pp.349-353, 2022 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 64 Issue: 4
  • Publication Date: 2022
  • Doi Number: 10.4103/indianjpsychiatry.indianjpsychiatry_26_22
  • Journal Name: Indian Journal of Psychiatry
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Social Sciences Citation Index (SSCI), Scopus, Academic Search Premier, CAB Abstracts, CINAHL, EMBASE, Directory of Open Access Journals
  • Page Numbers: pp.349-353
  • Keywords: Biomarkers, central nervous system, obsessive-compulsive disorder, vitamin D, D DEFICIENCY, CHILDREN, ADOLESCENTS, PREVALENCE, EXPRESSION
  • Kayseri University Affiliated: No


© 2022 Wolters Kluwer Medknow Publications. All rights reserved.Background: The impact of vitamin D on obsessive-compulsive disorder (OCD) remains unknown. Aim: Studies suggest that vitamin D deficiency may be associated with neuropsychiatric diseases. The purpose of this study is to investigate vitamin D levels in those diagnosed with OCD. In addition, the relation between OCD symptom severity and serum vitamin D level is investigated. Methods: About 174 patients newly diagnosed with OCD and 170 healthy volunteers were included in the study. Yale-Brown Obsessive Compulsive Scale (YBOCS) was used to assess the severity of OCD symptoms. Serum vitamin D levels of the two groups were compared. Results: The serum vitamin D levels of the OCD group were found to be significantly lower than the control group. Serum vitamin D levels were negatively correlated with the obsession, compulsion, and total scale scores measured in YBOCS but there was no correlation between the serum vitamin D levels and illness duration of OCD patients. Conclusions: To the best of our knowledge, this is one of the first studies to investigate vitamin D levels in newly diagnosed adult OCD patients without comorbidities. Although our findings suggest that vitamin D may play a role in the pathophysiology of OCD, further studies are needed to support our findings.