Investigation of interactions between COVID-19 and diabetes with hereditary traits using real data: A case study in Turkey

Özköse F., Yavuz M.

Computers in Biology and Medicine, vol.141, 2022 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 141
  • Publication Date: 2022
  • Doi Number: 10.1016/j.compbiomed.2021.105044
  • Journal Name: Computers in Biology and Medicine
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Applied Science & Technology Source, BIOSIS, Biotechnology Research Abstracts, CINAHL, Compendex, Computer & Applied Sciences, EMBASE, INSPEC, Library, Information Science & Technology Abstracts (LISTA), MEDLINE
  • Keywords: COVID-19 epidemic model, Parameter estimation, Diabetes, Fractional derivative, Stability analysis, Sensitivity analysis, Adams-Bashforth-Moulton scheme, Memory trace, EPIDEMIC, CORONAVIRUS, STABILITY, MODEL
  • Kayseri University Affiliated: No


© 2021 Elsevier LtdIn the present paper, interactions between COVID-19 and diabetes are investigated using real data from Turkey. Firstly, a fractional order pandemic model is developed both to examine the spread of COVID-19 and its relationship with diabetes. In the model, diabetes with and without complications are adopted by considering their relationship with the quarantine strategy. Then, the existence and uniqueness of solution are examined by using the fixed point theory. The dynamic behaviors of the equilibria and their stability analysis are studied. What is more, with the help of least-squares curve fitting technique (LSCFT), the fitting of the parameters is implemented to predict the direction of COVID-19 by using more accurately generated parameters. By trying to minimize the mean absolute relative error between the plotted curve for the infected class solution and the actual data of COVID-19, the optimal values of the parameters used in numerical simulations are acquired successfully. In addition, the numerical solution of the mentioned model is achieved through the Adams-Bashforth-Moulton predictor-corrector method. Meanwhile, the sensitivity analysis of the parameters according to the reproduction number is given. Moreover, numerical simulations of the model are obtained and the biological interpretations explaining the effects of model parameters are performed. Finally, in order to point out the advantages of the fractional order modeling, the memory trace and hereditary traits are taken into consideration. By doing so, the effect of the different fractional order derivatives on the COVID-19 pandemic and diabetes are investigated.