Akademik Veri Yönetim Sistemi
7th International Mediterranean Science and Engineering Congress, Antalya, Türkiye, 24 - 26 Ekim 2022, ss.54
: Recently, the design and synthesis of bioactive compounds in the field of chemistry have created important applications
and gains in medicine and pharmaceutical industries. Sulfur-containing dithiocarbonimidates or dithioimidocarbonates, which
have an important place among organic molecules, show pharmacological activities. These compounds are a class of stable
compounds that play an important role in S-containing molecules. Organic dithiocarbonimidates or dithioimidocarbonates are
widely used in agrochemicals, pharmaceuticals, intermediates in organic synthesis, radical precursors in free radical chemistry
and photochemistry, catalysis and polymerization reactions in sulfur vulcanization of rubber. Moreover, carbamate derivatives
or dithioimidocarbonates require investigation of medicinal and biological properties (antibacterial, anthelminic, fungicidal,
herbicidal, growth-reducing). In view of these important properties, we decided to extend our investigations related
to preparing new heterocycles, which include the pyrimidine ring in their structure. In this study, we reported the synthesis
of new pyrimidine-dithiocarbamates from reactions of compounds 3 and Propargyl bromide in presence of CS2
. Antioxidant
capacities of compounds synthesized within the scope of antioxidant experiments were determined spectrophotometrically
using DPPH• and ABTS• methods and Gaussian, Autudock Vina etc. The potential to become a drug was also investigated
with the programs. The structures of all new synthesized heterocyclic compounds are confirmed by spectroscopic and
elemental analyses.