© 2022, Institute of Chemistry, Slovak Academy of Sciences.Herein, for the first time, the flower-like enzyme–inorganic hybrid nanoflowers were synthesized using a superoxide dismutase (SOD) as organic material and selected some metal ions (Cu(II), Co(II), Mn(II) and Zn(II)) as inorganic parts at optimum pH value. The synthesis steps of SOD@metalphosphates hybrid nanoflowers were verified by XRD, FT-IR, FESEM, and EDX. The synthesized nanoflowers were utilized as a catalyst in the reduction of organic pollutants (2-nitrophenol (2-NP) and Rhodamine B (RhB)) with NaBH4 in aqueous media for catalytic properties and susceptibility. The activities of both the substrate and the metal center of the catalyst were determined in the increasing rate order of RhB > 2-NP for substrate and SOD@Cu3(PO4)2·3H2O > SOD@Co3(PO4)2·8H2O > SOD@Mn3(PO4)2·7H2O > SOD@Zn3(PO4)2.4H2O hNfs for catalysts. The catalytic data provided herein by using SOD@metalphosphates (SOD@Cu3(PO4)2·3H2O, SOD@Co3(PO4)2·8H2O, SOD@Mn3(PO4)2·7H2O and SOD@Zn3(PO4)2·4H2O) nanoflowers suggest that the materials can be effective catalysts for the water-based reduction reaction of organic pollutants. Graphical abstract: [Figure not available: see fulltext.].